Some of you may know Akshay Luther from his work on The GridBus Project, basically a grid computing project. Well, he is another Readify Blogger and he recently posted up some modifications to EntLib which allow it to store per-user settings in Isolated Storage.
We talked about this on our internal tech@ mailing list and Darren mentioned that you have to watch out for changing the application path (say via automatic updates) since its the key that unlocks isolated storage.